Heterotropic splenic autotransplantation in the prevention of Haemophilus influenza meningitis and fatal sepsis in Sprague-Dawley rats.

Heterotopic Splenic Autotranspiantation in the Prevention of Haemophilus influenzae Meningitis and Fatal Sepsis in Sprague-Dawley Rats

It has been suggested that autotransplantation of splenic tissue following trauma may result in splenic implants that protect the human host from severe infection with encapsulated bacteria. To test this hypothesis. Sprague-Dawley rats underwent sham operation. splenectomy. or splenectomy followed by autotransplantation of splenic fragments into the peritoneal cavity. Three months later. they w...

Preclinical safety testing of the Quimi-Hib® vaccine adjuvanted with aluminum phosphate during product development

Haemophilus influenzae type b (Hib) is a Gram-negative bacterium causing diseases such as meningitis, pneumonia, epiglottis, cellulitis, septicemia and arthritis, among others. Hib-caused meningitis / Hib meningitis is a very serious disease with a death rate of more than 50 % throughout the world; therefore obtaining a vaccine against this bacterium is a goal of the highest priority. The prese...

Antibody response to intravenous immunization following splenic tissue autotransplantation in Sprague-Dawley rats.

The response to intravenous challenge with sheep erythrocytes was determined in Sprague-Dawley rats following autotransplantation of splenic tissue into the subcutaneous tissue, peritoneal cavity, or a surgically created omental pouch. There was a marked rise in heterophil antibody titer following intravenous challenge in ten control animals, and no rise in titer in nine of ten asplenic animals...

Fatal neonatal septicaemia and meningitis due to Haemophilus influenzae acquired from the mother.

A fatal case of neonatal Haemophilus influenzae type b, septicaemia and meningitis is described. Although the mother was asymptomatic, maternal genital tract culture yielded H. influenzae which was indistinguishable from the strain found in the infant. Despite the rarity of this organism as a cause of neonatal sepsis, increased awareness is essential so that this important offending pathogen is...

Cerium Oxide Nanoparticles Attenuate Polymicrobial Sepsis Induced Splenic Damage in male Sprague Dawley Rats